A crash involving at least three vehicles prompted California Highway Patrol to issue a Sig Alert for Interstate 5 Wednesday night.
Six people were taken to the hospital after the crash, which started in the southbound lanes near Clairemont Drive at 8:10 p.m.
Their injuries are not life-threatening, according to San Diego fire officials.
The Sig Alert was lifted and the crash cleared at about 9:20 p.m.