A freight train derailed early Tuesday in the Barrio Logan area south of downtown near Cesar Chavez Parkway and Harbor Boulevard.
The derailment happened at 2:30 a.m., San Diego Police said.
The Burlington Northern Santa Fe train was traveling from New Mexico and nearing its final destination here in San Diego when two of the train cars derailed.
No one was injured in the incident and none of the cargo was damaged.
Amtrak schedules were not affected because the trains run on different tracks.