Two people have died in a wrong-way crash on State Route 76 in Pauma Valley on Friday morning, officials said.
A Sig Alert was issued, as SR-76 has been shut down between Pauma Valley Road and Valley Center Road, west of Palomar Mountain.
The section of roadway was reopened by 2:30 p.m.
The crash happened at about 10:30 a.m. in the 16600 block of SR-76, when the 24-year-old motorist was driving his 2002 Mazda Miata the wrong way and hit a 2014 box truck head on.
The Escondido driver of the Miata and his 27-year-old passenger of Carlsbad died instantly, California Highway Patrol officers said.
Two men in the other vehicle, a box truck -- ages 49 and 43 -- suffered minor injuries and were taken to Palomar Hospital.
Officers said the men in the box truck were unable to avoid the collision in time.
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Investigators don't yet know if alcohol or drugs played a factor. The crash remains under investigation.